The immune system keeps the body healthy by fighting off bacteria and viruses, however for people living with primary immunodeficiency disease (PID, sometimes known as PI, PIDD or inborn errors of immunity (IEI)) the immune system fails to do this. The defects in the immune system are present at birth, but symptoms may appear in infancy or later in life. Primary immunodeficiency isn’t a single disorder; it refers to a group of over 450 rare chronic conditions that affect a person’s immune system. PID can range in severity depending on the specific conditions involved. Primary immunodeficiency disorders include B cell deficiencies, T cell deficiencies, DiGeorge syndrome, and Kabuki syndrome.

PID (Primary immunodeficiency) is caused by genetic factors and having a family history is the biggest risk factor for developing an immunodeficiency (PI) disorder. The genetic factor makes primary immunodeficiency different from secondary immunodeficiency, which is due to a medication or a disease process. Once correctly diagnosed and treated, people with PID can live full and active lives.

The immune system keeps the body healthy by fighting off germs. But sometimes, due to external factors (those not caused by genetics) people develop what’s known as a secondary immunodeficiency (SID). Just like with a primary immunodeficiency, the outcome can be life marked by seemingly never-ending infections and colds that just don’t go away. As a result, people may face repeated rounds of antibiotics and hospitalization for treatment. SID is much more common than primary (genetic) immunodeficiencies.